Implementation-derived Down-syndrome-associated methylation projection score: pyaging computes a zero-intercept weighted sum of 652 neonatal blood-spot beta values using the paper's autosomal EWAS beta_overall effect estimates. The paper presents an EWAS, not a trained or validated Down syndrome classifier.
1import pyaging as pya
2
3pya.pred.predict_age(adata, ["downsyndrome"])
Browse every clock in the
pyaging Clock Catalogue.
Muskens, Ivo S., et al. "The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis." Nature Communications 12 (2021): 821.
