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YDXX/
ViroHyena-6m

Name: ViroHyena-6m
Availability: InStock

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ViroHyena-6.6M

ViroHyena is a Hyena-based nucleotide language model introduced in the paper ViroBench: Benchmarking Nucleotide Foundation Models on Viral Genomics Tasks.

This specific checkpoint is the 6.6M parameter version. It was pre-trained on the ViroBlend corpus, a 216 Mbp mixed pretraining dataset using source-wise stratified sampling to balance human reference, multi-species genomes, and viral in-domain sequences.

Resources

Paper: ViroBench: Benchmarking Nucleotide Foundation Models on Viral Genomics Tasks
Repository: GitHub - ViroBench

Model Configurations

Model	Params	d_model	Layers
ViroHyena-436K	0.436M	128	2
ViroHyena-1.6M	1.6M	256	2
ViroHyena-6.6M	6.6M	256	8
ViroHyena-253M	253M	1024	20

Biosecurity & Responsible Use

This model was developed for biological understanding and measurement research. As noted in the project documentation:

Do NOT use this model to design, optimize, synthesize, or operationalize harmful biological agents.
Follow all applicable laws, institutional policies, and biosafety regulations.
If you release checkpoints or generation outputs, consider controlled access and red-teaming protocols.

Citation

bibtex

@article{ye2026virobench,
  title={ViroBench: Benchmarking Nucleotide Foundation Models on Viral Genomics Tasks},
  author={Ye, Dongxin and Hu, Fang and Hu, Han and Hu, Shu and Tan, Yang and Ouyang, Wanli and Li, Stan Z and Cui, Jie and Dong, Nanqing},
  journal={arXiv preprint arXiv:2605.25388},
  year={2026}
}

YDXX/ViroHyena-6m