span-ai-labs/

oncotraj-v1

A public benchmark for longitudinal resistance prediction in EGFR-mutant non-small-cell lung cancer (NSCLC) on first-line osimertinib.

Headline finding. On clean within-source evaluation, snapshot (single-timepoint) features do not beat chance on any of the three tasks at this cohort size. The binding constraint is the data modality — single-timepoint tissue/ctDNA snapshots — not the model. Serial ctDNA trajectories are the precondition for above-chance performance.… See the full description on the dataset page: https://huggingface.co/datasets/span-ai-labs/oncotraj-v1.