nicolynnvila/

splicing_epistasis_okgp_cons_driver_tcgarec

10,864 cis-double SNV pairs across 41 genes: OncoKB cancer drivers, LOEUF<0.7, with ≥2 TCGA-clean pairs × ≥5 carriers each. Tests the RESCUE-enrichment hypothesis. Built with the standard paper §2 ¶1-5 methodology:

≤100 nt intra-gene window ≥3 1KG carriers per constituent TopLD r² ≥ 0.2 dropped Greedy 1:1 matched arms keyed on gene + log-rarity bin + distance ±2 nt seed=42

Companion panels:… See the full description on the dataset page: https://huggingface.co/datasets/nicolynnvila/splicing_epistasis_okgp_cons_driver_tcgarec.