Why this target matters. GID4 is one of the very few usable E3 handles beyond cereblon and VHL, and the degrader field's reliance on just two ligases is currently its central bottleneck.
1,567 de novo, generative-AI–designed small-molecule ligands docked into the
substrate-binding pocket of human GID4 (Glucose-Induced Degradation protein 4),
each provided as a protein–ligand complex in PDB format.
GID4 is the… See the full description on the dataset page:
https://huggingface.co/datasets/Tc-43/GID4_7SLZ_20260620.
