Why this target matters. Cereblon is the most clinically validated E3 ligase handle in medicine — the direct target of thalidomide, lenalidomide and pomalidomide, and the recruiting engine behind most molecular glues and PROTACs now in the clinic.
221 computationally designed small-molecule ligands docked into Cereblon (CRBN),
each provided as a single-file protein–ligand complex in PDB format (221 unique ligand structures).… See the full description on the dataset page:
https://huggingface.co/datasets/Tc-43/CRBN_Binders.
