Downloaded from SIGNOR 4.0 on 2/4/2026:
https://signor.uniroma2.it/downloads.php
Used the Complete Dataset for Homo sapiens
Filtered to entries where TYPEA=='protein' and TYPEB=='protein'
Filtered to entries where DIRECT=='YES'
Dropped entries where EFFECT=='uknown'
Dropped a single entry where EFFECT=='form complex'
Filtered to only include the shown columns (renamed)
Dropped duplicates
Assigned a label of 2 to entries whose EFFECT was 'binding', as well as entries for which the invert… See the full description on the dataset page:
https://huggingface.co/datasets/GleghornLab/Signor_processed.
