This dataset contains research-level prioritization assessments for RIT1 missense variants associated with Noonan Syndrome 8 (NS8). Each entry provides a structured analysis including source-derived investigation tiers, scores, and evidence summaries based on computational predictors, population frequency, and structural domain context. The data explicitly… See the full description on the dataset page: https://huggingface.co/datasets/Fernandosr85/adaption-rit1-vus-research-tiers.