Composite Systems Age integrates the 11 mortality-associated physiological-system scores plus a DNAm chronological-age prediction through PCA and Cox elastic-net regression, then rescales the result to an age-like value.
1import pyaging as pya
2
3pya.pred.predict_age(adata, ["systemsage"])
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Sehgal, R., Markov, Y., Qin, C., et al. (2025). Systems Age: a single blood methylation test to quantify aging heterogeneity across 11 physiological systems. Nature Aging, 5, 1880–1896.
