Blood methylation risk score for major depressive disorder built with penalised regression on genome-wide EPIC-array CpGs, trained on over 1,200 cases and 1,800 controls. Discriminates prevalent from incident MDD independently of polygenic risk, with a smoking-independent variant also derived.
1import pyaging as pya
2
3pya.pred.predict_age(adata, ["depressionbarbu"])
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Barbu, Miruna C., et al. "Epigenetic prediction of major depressive disorder." Molecular Psychiatry 26.9 (2021): 5112-5123.
