SPARE models for NiChart v2 (2025 release)

• Models trained for NiChart v2 release in 2025, trained on ISTAGING 2.0 & 2.5 & 3.0.
• Works with the NiChart_SPARE package. GitHub

Biomarker list (RG=Regression, CL=Classification)

• [RG] BA: Brain Age
• [CL] AD: Alzheimer's Disease
• [CL] T2D: Diabetes (Type 2)
• [CL] DB: Diabetes (general)
• [CL] HT: Hypertension
• [CL] HL: Hyperlipidemia
• [CL] SM: Smoking
• [CL] OB: Obesity
• [CL] MDD: Major Depression Disorder
• [CL] PSY: Psychosis / Schizophrenia

Features used

SPARE-{biomarker}:

• (Covars) + (DLMUSE ROI Volumes)
• Citation (coming soon)

SPARE-CVM-{biomarker}:

• (Covars) + (DLMUSE ROI Volume) + (DLWMLS ROI Volumes)
• Citation

(For inference) Input data schema (all ROI #s are MUSE ROI)

• Covars: Age (float), Sex_M (int/float male==1, female==0)
• DLMUSE ROI volumes (unharmonized): DL_MUSE_Volume_{ROI #}
• DLMUSE ROI volumes (harmonized): H_DL_MUSE_Volume_{ROI #}
• DLWMLS ROI volumes (unharmonized): DL_WLMLS_Volume_{ROI #}

Notes

• (2026) ISTAGING 3.0 based BA & AD models are now available.
• For MUSE ROI description, please refer to the link.