from diffusers import AutoPipelineForText2Image
import torch

pipeline = AutoPipelineForText2Image.from_pretrained('Wan-AI/Wan2.1-I2V-14B-480P-Diffusers', torch_dtype=torch.bfloat16).to('cuda')
pipeline.load_lora_weights('maDcaDDie/realistic_comicbook_style_wan_2_2_i2v_480p-lora', weight_name='realistic_comicbook_style_wan_2_2_i2v_480p_000001000.safetensors')
image = pipeline('a beautiful landscape').images[0]
image.save("my_image.png")

For more details, including weighting, merging and fusing LoRAs, check the documentation on loading LoRAs in diffusers