CpGPT Human Dependencies

Contents

dna_embeddings/
  homo_sapiens/
    nucleotide-transformer-v2-500m-multi-species/
      2001bp_dna_embeddings.mmap    # ~5 GB — pre-computed DNA sequence embeddings
ensembl_metadata.db                  # ~930 MB — Ensembl genome annotations
illumina_metadata.db                 # ~30 MB — Illumina array probe metadata

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What are these files?

• DNA embeddings: Pre-computed 1024-dimensional embeddings from the Nucleotide Transformer v2 (500M) model for 2001bp windows centered on each CpG site in the human genome. These provide the sequence context for CpGPT.
• Ensembl metadata: Genome annotations including gene locations, CpG island boundaries, and regulatory elements.
• Illumina metadata: Probe-level metadata for Illumina methylation arrays (27k, 450k, EPIC, EPICv2, MSA).

Related Repositories

• Model weights: lucascamillomd/cpgpt-models
• Mammalian dependencies: lucascamillomd/cpgpt-mammalian-dependencies
• Code & tutorials: CpGPT GitHub

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