Tc-43/

KRAS_CyclophilinA_MolecularGlue

Why this target matters. RAS is mutated in roughly a quarter of all human cancers, and the cyclophilin A tri-complex mechanism reaches KRAS in its active, GTP-bound state — the form conventional inhibitors cannot engage.

40 computationally designed small-molecule ligands docked into the KRAS · Cyclophilin A ternary complex, each provided as a single-file protein–ligand complex in PDB format (40 unique ligand… See the full description on the dataset page: https://huggingface.co/datasets/Tc-43/KRAS_CyclophilinA_MolecularGlue.