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Synthyra/
ESM3_small

Name: ESM3_small
Rating: 2.5 (38 reviews)

protein-language-model

fastplms

custom_code

mit

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ESM3 Small

Model overview

Synthyra/ESM3_small packages the biohub/esm3-sm-open-v1 checkpoint with the FastPLMs runtime for Hugging Face Transformers. It accepts sequence, structure, and function tracks prepared through the multimodal helpers.

The repository uses the standard Transformers loading interface with trust_remote_code=True. See Technical details for each registered class and whether its weights come from the checkpoint.

The sequence- and token-classification classes reuse the pretrained backbone, but their task heads are newly initialized. Fine-tune those heads before interpreting their logits as predictions.

Install and platform requirements

Install the direct dependencies published with this model:

bash

python -m pip install -r \
  "https://huggingface.co/Synthyra/ESM3_small/resolve/main/requirements.txt"

The FastPLMs implementation itself is embedded in the model repository. Transformers loads it through trust_remote_code=True.

This model requires Python 3.11-3.14, PyTorch 2.13, and Transformers 5.13.

The CPU gate covers small offline tests. Published checkpoint throughput and parity require the documented device tier.

The Hub quick start needs network access for the first download. For an air-gapped run, build the manifest-pinned local artifact first and use the offline example.

Quick start

python

from transformers import AutoModel

model_id = "Synthyra/ESM3_small"
model = AutoModel.from_pretrained(
    model_id,
    trust_remote_code=True,
    attn_implementation="sdpa",
).eval()

For offline validation, replace model_id with the manifest-built dist/hub/ESM3_small path. Pass local_files_only=True.

Attention backends

The quick start uses sdpa.

Available backends are eager, sdpa, flex_attention. Requesting an unavailable backend raises instead of silently changing implementation.

output_attentions=True can use the documented one-call eager fallback to materialize attention tensors. The configured backend does not change.

Dataset embeddings

The shared embedding mixin keeps input order and biological-position masking. It accepts sequences, identified records, mappings, or a FASTA path:

python

pooled = model.embed_dataset(
    ["MSTNPKPQRKTKRNT", "MKTIIALSYIFCLVFA"],
    batch_size=2,
    pooling=("mean", "std"),
)
residues = model.embed_dataset(
    ["MSTNPKPQRKTKRNT"],
    full_embeddings=True,
)
print(pooled[0].tensor.shape)   # (2 * d,)
print(residues[0].tensor.shape) # (l, d)

Set output and format="safetensors" or "sqlite" for transactional, bounded-memory storage. Resume checks input order, model state, tokenizer policy, backend, dtype, and pooling configuration before it appends data.

Downstream prediction

The sequence and token prediction AutoClasses use the checkpoint backbone and create a new, untrained classifier. Sequence labels have shape (b,). Residue labels have shape (b, l) and use -100 outside biological positions.

python

import torch
from transformers import AutoTokenizer
from transformers import (
    AutoModelForSequenceClassification,
    AutoModelForTokenClassification,
)

model_id = "Synthyra/ESM3_small"
sequence_model = AutoModelForSequenceClassification.from_pretrained(
    model_id, num_labels=2, trust_remote_code=True
).eval()
token_model = AutoModelForTokenClassification.from_pretrained(
    model_id, num_labels=3, trust_remote_code=True
).eval()
tokenizer = AutoTokenizer.from_pretrained(model_id, trust_remote_code=True)
sequences = ["MSTNPKPQRKTKRNT", "MKTIIALSYIFCLVFA"]
batch = tokenizer(sequences, padding=True, return_tensors="pt")
biological = batch["attention_mask"].bool()
for special_id in tokenizer.all_special_ids:
    biological &= batch["input_ids"].ne(special_id)

sequence_labels = torch.zeros(len(sequences), dtype=torch.long)
token_labels = torch.full_like(batch["input_ids"], -100)
token_labels[biological] = 0

with torch.inference_mode():
    sequence_output = sequence_model(**batch, labels=sequence_labels)
    token_output = token_model(**batch, labels=token_labels)
print(sequence_output.logits.shape)  # (b, 2)
print(token_output.logits.shape)     # (b, l, 3)

PEFT fine-tuning

Install the training dependencies. Then attach LoRA to the loaded checkpoint:

python -m pip install "datasets>=4.8,<5" "peft>=0.19,<0.20"

python

from peft import LoraConfig, TaskType, get_peft_model

peft_model = get_peft_model(
    sequence_model,
    LoraConfig(
        task_type=TaskType.SEQ_CLS,
        r=8,
        lora_alpha=16,
        target_modules="all-linear",
        modules_to_save=["classifier"],
    ),
)

This checkpoint advertises a classification head. Save the separately trained classifier with the adapter. All FastPLMs checkpoints follow the Transformers PreTrainedModel contract and can use PEFT. The ESM2-specific shipped CLI is an example, not a support boundary. Record the target modules, base revision, data identity, and trainable parameter scope.

Test-time training

TTT samples masked views of one protein and updates only injected low-rank adapters. Base checkpoint weights stay frozen:

python

from transformers import AutoModel

ttt_model = AutoModel.from_pretrained(
    "Synthyra/ESM3_small",
    trust_remote_code=True,
)
metrics = ttt_model.ttt(
    seq="MSTNPKPQRKTKRNT",
    ttt_config={"steps": 3, "batch_size": 1, "seed": 7},
)
ttt_model.save_pretrained("adapted", safe_serialization=True)
ttt_model.ttt_reset()
print(metrics)

Saved adapters retain their deterministic reset state. TTT adds latency and memory, can worsen an output, and does not show biological function.

Sequence inference and masked-sequence generation

ESM3 prepares its sequence input. This example uses the sequence track. The public input contract also supports structure and function tracks through the multimodal helpers:

python

import torch

batch = model.tokenize_sequences(
    ["MKTAYIAKQ", "GGGG"],
    device=model.device,
)
with torch.inference_mode():
    output = model(**batch)

print(output.last_hidden_state.shape)
print(output.logits.shape)
print(output.structure_logits.shape)
print(output.function_logits.shape)

When return_dict=False, ESM3 uses the standard base-model tuple prefix: last_hidden_state, then requested hidden_states and attentions. Multimodal logits and extensions follow this prefix. Use named fields for individual tracks.

Generate masked sequence positions with an explicit seed:

python

from fastplms.models.esm3.modeling_esm3 import FastESM3GenerationConfig

config = FastESM3GenerationConfig(
    num_steps=8,
    temperature=1.0,
    seed=7,
)
generated = model.generate("MK____A", config)
print(generated)

Underscores mark positions to generate. Model outputs are track predictions, not experimental measurements of structure or function.

Technical details

Inputs: Sequence, structure, and function tracks prepared through the multimodal helpers
Transformers classes: AutoConfig, AutoModel, AutoModelForSequenceClassification, AutoModelForTokenClassification
Checkpoint weights: AutoConfig = FastPLMs extension, AutoModel = pretrained, AutoModelForSequenceClassification = base weights + untrained task head, AutoModelForTokenClassification = base weights + untrained task head
Attention backends: eager, sdpa, flex_attention
Precision: default
BF16 execution: fp32_parameters_autocast
Generation contract: not_applicable
Dependencies: core
Weight publication allowed: true
Weight license status: resolved
Redistributable: true
Complete weight publication required: false

Validation and provenance

FastPLMs pins the checkpoint, upstream source revisions, state transformation, and required files in models.toml. Built artifacts record exact source identities and conversion details in source-record.json.

FastPLMs checkpoint: Synthyra/ESM3_small
Runtime revision: recorded separately in the built artifact and published commit
Runtime source identities: recorded in source-record.json
Official checkpoint: biohub/esm3-sm-open-v1
Artifact source: fast
State transform: esm3_to_fastplms_v1
Pinned upstreams: biohub-esm, biohub-transformers
Release tiers: check, compliance, feature, artifact, benchmark
Unresolved required file identities: 0

Release validation includes the compliance tier. Its evidence identifies the checkpoint, backend, dtype, hardware, inputs, and reference revision.

Declared tiers compare configuration, tokenizer behavior, state, and representative inference with the pinned reference. A nonzero unresolved count blocks release. Metadata alone does not show that a build passed, that a backend is faster, or that an output is biologically valid.

License

Checkpoint terms: MIT. The Hub model-card identifier is mit. The local artifact contains applicable source licenses, notices, attribution, and conversion records. Review them before use.