This model is used to predict protein stability (ΔΔG) for mutant amino acid sequence.

protein level regression

The dataset is from Mega-scale experimental analysis of protein folding stability in biology and design. We collect all protein sequences that have ΔΔG value.

Label is the ΔΔG (kcal/mol) value, the positive value means stable and the negetive value represents unstable, ranging from minus infinity to positive infinity.

Amino acid sequence

test_loss: 0.18

test_spearman: 0.92

lora_dropout: 0.0

lora_alpha: 16

target_modules: ["query", "key", "value", "intermediate.dense", "output.dense"]

modules_to_save: ["classifier"]

class: AdamW

betas: (0.9, 0.98)

weight_decay: 0.01

learning rate: 1e-4

epoch: 20

batch size: 64

precision: 16-mixed